Protein Purification
Abcam E-64d (Alo x istatin), cathepsin B and L inhibitor, 5MG
MW 342.4 Da, Purity >98%. Irreversible cell-permeable cathepsin B and L inhibitor. Inhibits calpain. Inhibits autophagy. Inhibits platelet proteolysis. Reduces brain amyloid-β levels. Shows neuroprotective effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical GSK3 InhIbItr 1 5mg
A GSK3β inhibitor (IC50 = 4.19 nM); decreases blood glucose levels in an OGTT in a rat model of high-fat diet and STZ-induced diabetes at 50 mg/kg
Cayman Chemical AutotaxIn InhIbItr Screeng 96
Autotaxin (ATX, Ectonucleotide Pyrophosphatase/Phosphodiesterase-2, ENPP-2, Lysophospholipase D) is a secreted lysophospholipase D that catalyzes the hydrolysis of lysophosphatidylcholine (LPC) to generate lysophosphatidic acid (LPA). LPA is a lipid mediator that activates G protein-coupled receptors and induces a variety of biological responses, such as neurogenesis, angiogenesis, smooth-muscle contraction, platelet aggregation, and wound healing. ATX-LPA signaling is involved in a range of pathologies including tumor progression and inflammation. Cayman’s Autotaxin Inhibitor Screening Assay provides a convenient method for screening human ATX inhibitors. ATX cleaves bis-(p-nitrophenyl) phosphate liberating p-nitrophenol, a yellow product that is measured at 405-415 nm.
Cayman Chemical Cdk9 InhIbItr 1mg
A Cdk9 inhibitor (IC50 = 39 nM); selective for Cdk9 over Cdk1-7 (IC50s = >1,000 nM for all); inhibits PRRSV replication in PRRSV-infected primary porcine alveolar macrophages at 6 to 200 nM
Cayman Chemical LMW-PTP InhIbItr Ihydrochl 1mg
An inhibitor of LMW-PTPA (IC50 = 0.8 µM); selective for LMW-PTPA over a panel of 15 protein tyrosine phosphatases but does inhibit LMW-PTPB activity by >50% at 40 µM; increases insulin-induced insulin receptor phosphorylation in HepG2 cells at 10 µM; improves glucose tolerance and decreases fasting plasma insulin levels in a mouse model of diet-induced obesity at 50 mg/kg per day
Cayman Chemical BRMBRG1 ATP InhIbItr 1 10mg
A dual inhibitor of BRM and BRG1 ATPase activities (IC50s = <0.005 µM for both); reduces expression of KRT80 in H1299 and RERF-LC-A1 cell lines; reduces tumor cell growth in a RERF-LC-A1 lung cancer mouse xenograft model at 20mg/kg
Cayman Chemical STAT3 InhIbItr 4m 10mg
A STAT3 inhibitor; inhibits the phosphorylation of STAT3 and decreases levels of survivin and Mcl-1 in HCT116 cells at 0.75 and 1 µM; inhibits the proliferation of A549, HCT116, and HepG2 cells (IC50s = 0.93, 0.61, and 1.79 µM, respectively); induces apoptosis and cell cycle arrest at both the S and G2/M phases in HCT116 cells at 5 µM; reduces the viability of human CCOs from 1-10 µM
Cayman Chemical ASK1 InhIbItr 10 10mg
An orally bioavailable inhibitor of ASK1 (IC50 = 14 nM); selective for ASK1 over ASK2 (IC50 = 510 nM) as well as MEKK1, TAK-1, IKKβ, ERK1, JNK1, p38α, GSK3β, PKCθ, and B-RAF (IC50s = >10,000 nM for all); inhibits streptozotocin-induced increases in JNK and p38 phosphorylation in INS-1 pancreatic β cells in a concentration-dependent manner
Cayman Chemical PD-1PD-L1 InhIbItr 3trIfl 1mg
A PD-1/PD-L1 interaction inhibitor (IC50 = 9 nM in a TR-FRET assay)
Cayman Chemical IRAK InhIbItr 1 5mg
An IRAK4 inhibitor (IC50 = 35 nM); selective for IRAK4 over JNK1 and JNK2 at 10 µM; prevents increases in TNF-α and IL-12p40 levels in M. bovis-infected THP-1 cells at 1 µM
Abcam Protease Inhibitor Cocktail (100 x ), 3ML
Protease inhibitor cocktail (100X) is a comprehensive reagent designed to inhibit proteases during protein extraction from various cell types, including mammalian, yeast, fungal cells, and bacteria. - Broad-spectrum inhibition – inhibits aminopeptidases, metalloproteases, and serine, cysteine, and aspartic acid proteases - Includes EDTA – chelates divalent metal ions for enhanced protection against metalloproteases - Compatible with most protein extraction – ideal for general-purpose protease inhibition - Form – 100X stock solutions of protease inhibitors and EDTA, supplied separately Note: For techniques incompatible with EDTA, use Protease Inhibitor Cocktail EDTA Free (ab270055)
The product is subject to the following: Abcam Restricted Use Statement
Abcam FAK Inhibitor 14 (mM/ml), FAK autophosphorylation inhibitor, 20MM_ML
MW 174.63 Da. Selective focal adhesion kinase (FAK) autophosphorylation inhibitor (IC₅₀ = 1 μM). No significant activity at other kinases including EGFR, PDGFR and IGF-RI. Increases cell detachment and inhibits cell adhesion in cancer cells. Anticancer agent. Active in vivo and in vitro.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical GSK3 InhIbItr 1 50mg
A GSK3β inhibitor (IC50 = 4.19 nM); decreases blood glucose levels in an OGTT in a rat model of high-fat diet and STZ-induced diabetes at 50 mg/kg
Cayman Chemical PP1Src InhIbItr 5mg
A potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases: p56lck (IC50 = 5 nM), p59fynT (IC50 = 6 nM), Hck (IC50 = 20 nM)
Abcam TAPI-1, TNF alpha processing inhibitor, 1MG
MW 499.6 Da, Purity >95%. Stable, selective inhibitor of TNF-α processing (IC₅₀ = ~100 nM). Inhibits TACE (P< 0.01) and other metalloproteases in vivo. Blocks release of TNF-α (IC₅₀ = 50-100 μM), APP (IC₅₀ = 1-8 μM), ACE (IC₅₀ = 10 μM), IL6R (IC₅₀ = 5-10 μM), TNFRI (IC₅₀ = 5-10 μM), TNFRII (IC₅₀ = 25-50 μM), and ObRa (leptin receptor), but not CSF-1 in vivo. Structural analog of TAPI-0.
The product is subject to the following: Abcam Restricted Use Statement